人 APEH (NM_001640) cDNA克隆

Accession: NM_001640
基因名称: APEH
基因别名: APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2
基因描述: Homo sapiens acylaminoacyl-peptide hydrolase (APEH), mRNA.
种属: Human
CDS区长度: 2199 (查看编码区序列)
翻译后氨基酸长度: 732 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G102503 人 APEH (NM_001640) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]