人 TAB3 (NM_152787) cDNA克隆

Accession: NM_152787
基因名称: TAB3
基因别名: NAP1; MAP3K7IP3
基因描述: Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3), mRNA.
种属: Human
CDS区长度: 2139 (查看编码区序列)
翻译后氨基酸长度: 712 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G104303 人 TAB3 (NM_152787) cDNA克隆 pDONR223 2ug质粒 点击询价

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]