人 P4HB (NM_000918) cDNA克隆

Accession: NM_000918
基因名称: P4HB
基因别名: DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta
基因描述: Homo sapiens prolyl 4-hydroxylase, beta polypeptide (P4HB), mRNA.
种属: Human
CDS区长度: 1527 (查看编码区序列)
翻译后氨基酸长度: 508 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G105198 人 P4HB (NM_000918) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]