人 ECH1 (NM_001398) cDNA克隆

Accession: NM_001398
基因名称: ECH1
基因别名: HPXEL
基因描述: Homo sapiens enoyl CoA hydratase 1, peroxisomal (ECH1), mRNA.
种属: Human
CDS区长度: 987 (查看编码区序列)
翻译后氨基酸长度: 328 (查看氨基酸序列)
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G105868 人 ECH1 (NM_001398) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]