人 HLA-DQB2 (NM_001198858) cDNA克隆

Accession: NM_001198858
基因名称: HLA-DQB2
基因别名: HLA-DXB; HLA-DQB1
基因描述: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), mRNA.
种属: Human
CDS区长度: 684 (查看编码区序列)
翻译后氨基酸长度: 227 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G108372 人 HLA-DQB2 (NM_001198858) cDNA克隆 pDONR223 2ug质粒 点击询价

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]