人 NANS (NM_018946) cDNA克隆

Accession: NM_018946
基因名称: NANS
基因别名: SAS
基因描述: Homo sapiens N-acetylneuraminic acid synthase (NANS), mRNA.
种属: Human
CDS区长度: 1080 (查看编码区序列)
翻译后氨基酸长度: 359 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G110226 人 NANS (NM_018946) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]