人 PADI2 (NM_007365) cDNA克隆

Accession: NM_007365
基因名称: PADI2
基因别名: PAD2; PDI2; PAD-H19
基因描述: Homo sapiens peptidyl arginine deiminase, type II (PADI2), mRNA.
种属: Human
CDS区长度: 1998 (查看编码区序列)
翻译后氨基酸长度: 665 (查看氨基酸序列)
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G111020 人 PADI2 (NM_007365) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]