Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
人 ST6GALNAC1 (NM_018414) cDNA克隆
| Accession: | NM_018414 |
|---|---|
| 基因名称: | ST6GALNAC1 |
| 基因别名: | STYI; SIAT7A; HSY11339; ST6GalNAcI |
| 基因描述: | Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1), mRNA. |
| 种属: | Human |
| CDS区长度: | 1803 (查看编码区序列) |
| 翻译后氨基酸长度: | 600 (查看氨基酸序列) |
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