人 AGT (NM_000029) cDNA克隆

Accession: NM_000029
基因名称: AGT
基因别名: ANHU; SERPINA8
基因描述: Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT), mRNA.
种属: Human
CDS区长度: 1458 (查看编码区序列)
翻译后氨基酸长度: 485 (查看氨基酸序列)
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G111596 人 AGT (NM_000029) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]