人 HBA1 (NM_000558) cDNA克隆

Accession: NM_000558
基因名称: HBA1
基因别名: HBH; CD31
基因描述: Homo sapiens hemoglobin, alpha 1 (HBA1), mRNA.
种属: Human
CDS区长度: 429 (查看编码区序列)
翻译后氨基酸长度: 142 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G114595 人 HBA1 (NM_000558) cDNA克隆 pDONR223 2ug质粒 点击询价

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]