人 GRM3 (NM_000840) cDNA克隆

Accession: NM_000840
基因名称: GRM3
基因别名: GLUR3; mGlu3; GPRC1C; MGLUR3
基因描述: Homo sapiens glutamate receptor, metabotropic 3 (GRM3), mRNA.
种属: Human
CDS区长度: 2640 (查看编码区序列)
翻译后氨基酸长度: 879 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G115917 人 GRM3 (NM_000840) cDNA克隆 pDONR223 2ug质粒 点击询价

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]