人 CCNE2 (NM_057749) cDNA克隆

Accession: NM_057749
基因名称: CCNE2
基因别名: CYCE2
基因描述: Homo sapiens cyclin E2 (CCNE2), mRNA.
种属: Human
CDS区长度: 1215 (查看编码区序列)
翻译后氨基酸长度: 404 (查看氨基酸序列)
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G118841 人 CCNE2 (NM_057749) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]