人 ATM (NM_000051) cDNA克隆

Accession: NM_000051
基因名称: ATM
基因别名: AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
基因描述: Homo sapiens ataxia telangiectasia mutated (ATM), mRNA.
种属: Human
CDS区长度: 9171 (查看编码区序列)
翻译后氨基酸长度: 3056 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G119934 人 ATM (NM_000051) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]