人 ACER1 (NM_133492) cDNA克隆

Accession: NM_133492
基因名称: ACER1
基因别名: ASAH3; ALKCDase1
基因描述: Homo sapiens alkaline ceramidase 1 (ACER1), mRNA.
种属: Human
CDS区长度: 795 (查看编码区序列)
翻译后氨基酸长度: 264 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G129688 人 ACER1 (NM_133492) cDNA克隆 pDONR223 2ug质粒 点击询价

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]