人 DCC (NM_005215) cDNA克隆

Accession: NM_005215
基因名称: DCC
基因别名: CRC18; CRCR1; MRMV1; IGDCC1
基因描述: Homo sapiens deleted in colorectal carcinoma (DCC), mRNA.
种属: Human
CDS区长度: 4344 (查看编码区序列)
翻译后氨基酸长度: 1447 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G132758 人 DCC (NM_005215) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]