人 ABCG5 (NM_022436) cDNA克隆

Accession: NM_022436
基因名称: ABCG5
基因别名: STSL
基因描述: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), mRNA.
种属: Human
CDS区长度: 1956 (查看编码区序列)
翻译后氨基酸长度: 651 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G157826 人 ABCG5 (NM_022436) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]