小鼠 Sepn1 (NM_029100) cDNA克隆

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. The function of this gene in mouse is not known, however, mutations in the homologous gene in human are associated with multiminicore disease and rigid spine muscular dystrophy. [provided by RefSeq, Jul 2008]