人 MAFK (NM_002360) cDNA克隆

Accession: NM_002360
基因名称: MAFK
基因别名: P18; NFE2U
基因描述: Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), mRNA.
种属: Human
CDS区长度: 471 (查看编码区序列)
翻译后氨基酸长度: 156 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G165453 人 MAFK (NM_002360) cDNA克隆 pDONR223 2ug质粒 点击询价

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]