人 F5 (NM_000130) cDNA克隆

Accession: NM_000130
基因名称: F5
基因别名: FVL; PCCF; THPH2; RPRGL1
基因描述: Homo sapiens coagulation factor V (proaccelerin, labile factor) (F5), mRNA.
种属: Human
CDS区长度: 6675 (查看编码区序列)
翻译后氨基酸长度: 2224 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G168879 人 F5 (NM_000130) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]