人 C4B (NM_001002029) cDNA克隆

Accession: NM_001002029
基因名称: C4B
基因别名: CH; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4BD; C4B12; C4B_2; CPAMD3
基因描述: Homo sapiens complement component 4B (Chido blood group) (C4B), mRNA.
种属: Human
CDS区长度: 5235 (查看编码区序列)
翻译后氨基酸长度: 1744 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G172518 人 C4B (NM_001002029) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]