人 RTN3 (NM_201430) cDNA克隆

基本信息

Accession: NM_201430
基因名称: RTN3
基因别名: HAP; ASYIP; NSPL2; NSPLII; RTN3-A1
基因描述: Homo sapiens reticulon 3 (RTN3), transcript variant 4, mRNA.
种属: Human
CDS区长度: 726 (查看编码区序列)
翻译后氨基酸长度: 241 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is longer and has a distinct C-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G100669 人 RTN3 (NM_201430) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RTN3 (NM_006054) cDNA克隆 transcript variant 1
人 RTN3 (NM_201428) cDNA克隆 transcript variant 2
人 RTN3 (NM_201429) cDNA克隆 transcript variant 3
人 RTN3 (NM_201430) cDNA克隆 transcript variant 4
人 RTN3 (NM_001265589) cDNA克隆 transcript variant 5
人 RTN3 (NM_001265590) cDNA克隆 transcript variant 6
人 RTN3 (NM_001265591) cDNA克隆 transcript variant 7

基因简介

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

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