人 SPINT2 (NM_001166103) cDNA克隆

Accession: NM_001166103
基因名称: SPINT2
基因别名: PB; Kop; HAI2; DIAR3; HAI-2
基因描述: Homo sapiens serine peptidase inhibitor, Kunitz type, 2 (SPINT2), transcript variant b, mRNA.
种属: Human
CDS区长度: 588 (查看编码区序列)
翻译后氨基酸长度: 195 (查看氨基酸序列)
Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a. The resulting isoform (b) lacks an internal segment near the N-terminus, compared to isoform a.
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G100819 人 SPINT2 (NM_001166103) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]