人 GCLC (NM_001197115) cDNA克隆

基本信息

Accession: NM_001197115
基因名称: GCLC
基因别名: GCL; GCS; GLCL; GLCLC
基因描述: Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1800 (查看编码区序列)
翻译后氨基酸长度: 599 (查看氨基酸序列)
Transcript Variant: This variant (2, also referred to as delta4) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G100824 人 GCLC (NM_001197115) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GCLC (NM_001498) cDNA克隆 transcript variant 1
人 GCLC (NM_001197115) cDNA克隆 transcript variant 2

基因简介

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

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