人 PACRG (NM_152410) cDNA克隆

Accession: NM_152410
基因名称: PACRG
基因别名: GLUP; PARK2CRG; HAK005771; RP3-495O10.2
基因描述: Homo sapiens PARK2 co-regulated (PACRG), transcript variant 1, mRNA.
种属: Human
CDS区长度: 891 (查看编码区序列)
翻译后氨基酸长度: 296 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
产品编号 产品名称 载体 规格 价格
G100868 人 PACRG (NM_152410) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]