人 NFKBIB (NM_002503) cDNA克隆

Accession: NM_002503
基因名称: NFKBIB
基因别名: IKBB; TRIP9
基因描述: Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1071 (查看编码区序列)
翻译后氨基酸长度: 356 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
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G101339 人 NFKBIB (NM_002503) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]