人 ENO1 (NM_001201483) cDNA克隆

基本信息

Accession: NM_001201483
基因名称: ENO1
基因别名: NNE; PPH; MPB1; ENO1L1
基因描述: Homo sapiens enolase 1, (alpha) (ENO1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1026 (查看编码区序列)
翻译后氨基酸长度: 341 (查看氨基酸序列)
Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, and initiates translation from an in-frame downstream start codon, resulting in a shorter isoform (MBP-1). This isoform is localized to the nucleus, and functions as a transcriptional repressor of c-myc protooncogene by binding to its promoter (PMID:20849415).

订购信息

产品编号 产品名称 载体 规格 价格
G101903 人 ENO1 (NM_001201483) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ENO1 (NM_001428) cDNA克隆 transcript variant 1
人 ENO1 (NM_001201483) cDNA克隆 transcript variant 2

基因简介

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

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