人 SQSTM1 (NM_001142298) cDNA克隆

基本信息

Accession: NM_001142298
基因名称: SQSTM1
基因别名: p60; p62; A170; OSIL; PDB3; ZIP3; p62B
基因描述: Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1071 (查看编码区序列)
翻译后氨基酸长度: 356 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an in-frame downstream start codon compared to variant 1. This results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.

订购信息

产品编号 产品名称 载体 规格 价格
G101937 人 SQSTM1 (NM_001142298) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SQSTM1 (NM_003900) cDNA克隆 transcript variant 1
人 SQSTM1 (NM_001142298) cDNA克隆 transcript variant 2
人 SQSTM1 (NM_001142299) cDNA克隆 transcript variant 3

基因简介

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

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