人 SHC1 (NM_003029) cDNA克隆

基本信息

Accession: NM_003029
基因名称: SHC1
基因别名: SHC; SHCA
基因描述: Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1425 (查看编码区序列)
翻译后氨基酸长度: 474 (查看氨基酸序列)
Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.

订购信息

产品编号 产品名称 载体 规格 价格
G102107 人 SHC1 (NM_003029) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SHC1 (NM_183001) cDNA克隆 transcript variant 1
人 SHC1 (NM_003029) cDNA克隆 transcript variant 2
人 SHC1 (NM_001130040) cDNA克隆 transcript variant 3
人 SHC1 (NM_001130041) cDNA克隆 transcript variant 4
人 SHC1 (NM_001202859) cDNA克隆 transcript variant 5

基因简介

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

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