This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
人 LSM1 (NM_014462) cDNA克隆
| Accession: | NM_014462 |
|---|---|
| 基因名称: | LSM1 |
| 基因别名: | CASM; YJL124C |
| 基因描述: | Homo sapiens LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM1), transcript variant 1, mRNA. |
| 种属: | Human |
| CDS区长度: | 402 (查看编码区序列) |
| 翻译后氨基酸长度: | 133 (查看氨基酸序列) |
| Transcript Variant: | This variant (1) represents the longest transcript and is protein-coding. |
| 人 LSM1 (NM_014462) cDNA克隆 | transcript variant 1 |
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