人 NR1I2 (NM_022002) cDNA克隆

Accession: NM_022002
基因名称: NR1I2
基因别名: BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq
基因描述: Homo sapiens nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1422 (查看编码区序列)
翻译后氨基酸长度: 473 (查看氨基酸序列)
Transcript Variant: This variant (2) encodes the longest isoform (2) and initiates translation from the standard AUG codon present in its 5' terminal exon.
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G103867 人 NR1I2 (NM_022002) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]