人 YTHDF2 (NM_016258) cDNA克隆

Accession: NM_016258
基因名称: YTHDF2
基因别名: HGRG8; NY-REN-2
基因描述: Homo sapiens YTH domain family, member 2 (YTHDF2), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1740 (查看编码区序列)
翻译后氨基酸长度: 579 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longer isoform (1).
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G104143 人 YTHDF2 (NM_016258) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]