人 BAD (NM_032989) cDNA克隆

Accession: NM_032989
基因名称: BAD
基因别名: BBC2; BCL2L8
基因描述: Homo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 2, mRNA.
种属: Human
CDS区长度: 507 (查看编码区序列)
翻译后氨基酸长度: 168 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
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G105103 人 BAD (NM_032989) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]