人 ETS1 (NM_001162422) cDNA克隆

基本信息

Accession: NM_001162422
基因名称: ETS1
基因别名: ETS-1; EWSR2
基因描述: Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 678 (查看编码区序列)
翻译后氨基酸长度: 225 (查看氨基酸序列)
Transcript Variant: This variant (3) uses an alternate promoter, and differs in the 5' UTR and 5' coding region compared to variant 1. It is also missing four consecutive in-frame coding exons, resulting in a shorter isoform (3, also known as Ets-1 p27) with a distinct N-terminus and lacking an internal protein segment compared to isoform 1. This isoform has been shown to exert a dominant negative effect on the transcriptional properties and the subcellular localization of Ets-1 p51 isoform (PMID:19377509).

订购信息

产品编号 产品名称 载体 规格 价格
G105593 人 ETS1 (NM_001162422) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ETS1 (NM_001143820) cDNA克隆 transcript variant 1
人 ETS1 (NM_005238) cDNA克隆 transcript variant 2
人 ETS1 (NM_001162422) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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