人 TGIF1 (NM_173208) cDNA克隆

基本信息

Accession: NM_173208
基因名称: TGIF1
基因别名: HPE4; TGIF
基因描述: Homo sapiens TGFB-induced factor homeobox 1 (TGIF1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 819 (查看编码区序列)
翻译后氨基酸长度: 272 (查看氨基酸序列)
Transcript Variant: This variant (3) includes two alternate 5' exons, which result in a different 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. Variants 3, 4 and 10 encode the same isoform c.

订购信息

产品编号 产品名称 载体 规格 价格
G106499 人 TGIF1 (NM_173208) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TGIF1 (NM_170695) cDNA克隆 transcript variant 1
人 TGIF1 (NM_001278684) cDNA克隆 transcript variant 10
人 TGIF1 (NM_001278686) cDNA克隆 transcript variant 11
人 TGIF1 (NM_173207) cDNA克隆 transcript variant 2
人 TGIF1 (NM_173208) cDNA克隆 transcript variant 3
人 TGIF1 (NM_003244) cDNA克隆 transcript variant 4
人 TGIF1 (NM_173209) cDNA克隆 transcript variant 5
人 TGIF1 (NM_173210) cDNA克隆 transcript variant 6
人 TGIF1 (NM_173211) cDNA克隆 transcript variant 7
人 TGIF1 (NM_174886) cDNA克隆 transcript variant 8
人 TGIF1 (NM_001278682) cDNA克隆 transcript variant 9

基因简介

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

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