人 DCTN2 (NM_006400) cDNA克隆

Accession: NM_006400
基因名称: DCTN2
基因别名: RBP50; DCTN50; DYNAMITIN
基因描述: Homo sapiens dynactin 2 (p50) (DCTN2), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1221 (查看编码区序列)
翻译后氨基酸长度: 406 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longest isoform (1).
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G106507 人 DCTN2 (NM_006400) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]