This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
人 STAM (NM_003473) cDNA克隆
| Accession: | NM_003473 |
|---|---|
| 基因名称: | STAM |
| 基因别名: | STAM1; STAM-1 |
| 基因描述: | Homo sapiens signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 (STAM), transcript variant 1, mRNA. |
| 种属: | Human |
| CDS区长度: | 1623 (查看编码区序列) |
| 翻译后氨基酸长度: | 540 (查看氨基酸序列) |
| Transcript Variant: | This variant (1) represents the longer transcript and encodes a functional protein. |
| 人 STAM (NM_003473) cDNA克隆 | transcript variant 1 |
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