人 CASP2 (NM_032982) cDNA克隆

基本信息

Accession: NM_032982
基因名称: CASP2
基因别名: ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57
基因描述: Homo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1359 (查看编码区序列)
翻译后氨基酸长度: 452 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longest isoform (1, also known as ICH-1L), which has been shown to function as a positive regulator of apoptosis (PMID:8087842).

订购信息

产品编号 产品名称 载体 规格 价格
G106743 人 CASP2 (NM_032982) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CASP2 (NM_032982) cDNA克隆 transcript variant 1
人 CASP2 (NM_001224) cDNA克隆 transcript variant 2
人 CASP2 (NM_032983) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

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