人 CRK (NM_016823) cDNA克隆

基本信息

Accession: NM_016823
基因名称: CRK
基因别名: p38; CRKII
基因描述: Homo sapiens v-crk avian sarcoma virus CT10 oncogene homolog (CRK), transcript variant II, mRNA.
种属: Human
CDS区长度: 915 (查看编码区序列)
翻译后氨基酸长度: 304 (查看氨基酸序列)
Transcript Variant: This variant (II) includes an alternate segment, compared to variant I, resulting in a longer protein (isoform a) that has a distinct C-terminus and an additional SH3 domain, compared to isoform b. Isoform a is a negative modulator of transformation activity.

订购信息

产品编号 产品名称 载体 规格 价格
G108139 人 CRK (NM_016823) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CRK (NM_005206) cDNA克隆 transcript variant I
人 CRK (NM_016823) cDNA克隆 transcript variant II

基因简介

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

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