人 IL24 (NM_001185157) cDNA克隆

基本信息

Accession: NM_001185157
基因名称: IL24
基因别名: C49A; FISP; MDA7; MOB5; ST16; IL10B
基因描述: Homo sapiens interleukin 24 (IL24), transcript variant 4, mRNA.
种属: Human
CDS区长度: 465 (查看编码区序列)
翻译后氨基酸长度: 154 (查看氨基酸序列)
Transcript Variant: This variant (4, also known as IL-24 delE5) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G108172 人 IL24 (NM_001185157) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 IL24 (NM_006850) cDNA克隆 transcript variant 1
人 IL24 (NM_001185156) cDNA克隆 transcript variant 3
人 IL24 (NM_001185157) cDNA克隆 transcript variant 4
人 IL24 (NM_001185158) cDNA克隆 transcript variant 5

基因简介

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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