人 DIABLO (NM_001278302) cDNA克隆

基本信息

Accession: NM_001278302
基因名称: DIABLO
基因别名: SMAC; DFNA64
基因描述: Homo sapiens diablo, IAP-binding mitochondrial protein (DIABLO), transcript variant 5, mRNA.
种属: Human
CDS区长度: 429 (查看编码区序列)
翻译后氨基酸长度: 142 (查看氨基酸序列)
Transcript Variant: This variant (5) differs in its 5' UTR and 5' coding region, uses an alternate start codon, and lacks an in-frame exon in the internal coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G108426 人 DIABLO (NM_001278302) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DIABLO (NM_019887) cDNA克隆 transcript variant 1
人 DIABLO (NM_138930) cDNA克隆 transcript variant 2
人 DIABLO (NM_001278342) cDNA克隆 transcript variant 3
人 DIABLO (NM_001278302) cDNA克隆 transcript variant 5
人 DIABLO (NM_001278303) cDNA克隆 transcript variant 6
人 DIABLO (NM_001278304) cDNA克隆 transcript variant 7

基因简介

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

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