人 KLK7 (NM_001243126) cDNA克隆

基本信息

Accession: NM_001243126
基因名称: KLK7
基因别名: hK7; SCCE; PRSS6
基因描述: Homo sapiens kallikrein-related peptidase 7 (KLK7), transcript variant 4, mRNA.
种属: Human
CDS区长度: 741 (查看编码区序列)
翻译后氨基酸长度: 246 (查看氨基酸序列)
Transcript Variant: This variant (4) uses an alternate upstream start codon, compared to variant 1, which is only present in the minor allele due to a single nucleotide polymorphism. The 5' CDS is in a different reading frame, but this variant lacks an exon in the coding region which results in a frameshift and in-frame 3' CDS, compared to variant 1. The encoded isoform (3) has a unique N-terminus and is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G108639 人 KLK7 (NM_001243126) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 KLK7 (NM_005046) cDNA克隆 transcript variant 1
人 KLK7 (NM_139277) cDNA克隆 transcript variant 2
人 KLK7 (NM_001207053) cDNA克隆 transcript variant 3
人 KLK7 (NM_001243126) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

相关产品