RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Accession: | NM_014715 |
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基因名称: | ARHGAP32 |
基因别名: | GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP |
基因描述: | Homo sapiens Rho GTPase activating protein 32 (ARHGAP32), transcript variant 2, mRNA. |
种属: | Human |
CDS区长度: | 5217 (查看编码区序列) |
翻译后氨基酸长度: | 1738 (查看氨基酸序列) |
Transcript Variant: | This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1. |
人 ARHGAP32 (NM_001142685) cDNA克隆 | transcript variant 1 |
人 ARHGAP32 (NM_014715) cDNA克隆 | transcript variant 2 |
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]