人 B4GALT4 (NM_003778) cDNA克隆

Accession: NM_003778
基因名称: B4GALT4
基因别名: B4Gal-T4; beta4Gal-T4
基因描述: Homo sapiens UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 (B4GALT4), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1035 (查看编码区序列)
翻译后氨基酸长度: 344 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
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G110045 人 B4GALT4 (NM_003778) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]