人 NR1H3 (NM_001251934) cDNA克隆

基本信息

Accession: NM_001251934
基因名称: NR1H3
基因别名: LXRA; LXR-a; RLD-1
基因描述: Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1362 (查看编码区序列)
翻译后氨基酸长度: 453 (查看氨基酸序列)
Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.

订购信息

产品编号 产品名称 载体 规格 价格
G110551 人 NR1H3 (NM_001251934) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NR1H3 (NM_005693) cDNA克隆 transcript variant 1
人 NR1H3 (NM_001130101) cDNA克隆 transcript variant 2
人 NR1H3 (NM_001130102) cDNA克隆 transcript variant 3
人 NR1H3 (NM_001251934) cDNA克隆 transcript variant 4
人 NR1H3 (NM_001251935) cDNA克隆 transcript variant 5

基因简介

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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