人 GABRB3 (NM_001191320) cDNA克隆

基本信息

Accession: NM_001191320
基因名称: GABRB3
基因别名: ECA5
基因描述: Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1167 (查看编码区序列)
翻译后氨基酸长度: 388 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks three exons in the 5' coding region and initiates translation at an in-frame downstream start codon, compared to variant 1. Variants 3 and 5 encode the same isoform (3), which is shorter at the N-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G111421 人 GABRB3 (NM_001191320) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GABRB3 (NM_000814) cDNA克隆 transcript variant 1
人 GABRB3 (NM_021912) cDNA克隆 transcript variant 2
人 GABRB3 (NM_001191320) cDNA克隆 transcript variant 3
人 GABRB3 (NM_001191321) cDNA克隆 transcript variant 4
人 GABRB3 (NM_001278631) cDNA克隆 transcript variant 5

基因简介

This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

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