人 BAIAP2 (NM_017450) cDNA克隆

Accession: NM_017450
基因名称: BAIAP2
基因别名: BAP2; FLAF3; IRSP53
基因描述: Homo sapiens BAI1-associated protein 2 (BAIAP2), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1566 (查看编码区序列)
翻译后氨基酸长度: 521 (查看氨基酸序列)
Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-alpha, short form, or variant S.
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G111996 人 BAIAP2 (NM_017450) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]