人 KCNA3 (NM_002232) cDNA克隆

Accession: NM_002232
基因名称: KCNA3
基因别名: MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII; RP11-284N8.3
基因描述: Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 3 (KCNA3), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1728 (查看编码区序列)
翻译后氨基酸长度: 575 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G111998 人 KCNA3 (NM_002232) cDNA克隆 pDONR223 2ug质粒 点击询价

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]