HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
人 HNRNPLL (NM_001142650) cDNA克隆
| Accession: | NM_001142650 |
|---|---|
| 基因名称: | HNRNPLL |
| 基因别名: | SRRF; HNRPLL |
| 基因描述: | Homo sapiens heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 1614 (查看编码区序列) |
| 翻译后氨基酸长度: | 537 (查看氨基酸序列) |
| Transcript Variant: | Compared to variant 1, this variant (2) lacks a segment of the 5' UTR which results in the use of an alternative translation initiation site. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1. |
| 人 HNRNPLL (NM_138394) cDNA克隆 | transcript variant 1 |
| 人 HNRNPLL (NM_001142650) cDNA克隆 | transcript variant 2 |
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