The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
人 GPNMB (NM_001005340) cDNA克隆
| Accession: | NM_001005340 |
|---|---|
| 基因名称: | GPNMB |
| 基因别名: | NMB; HGFIN |
| 基因描述: | Homo sapiens glycoprotein (transmembrane) nmb (GPNMB), transcript variant 1, mRNA. |
| 种属: | Human |
| CDS区长度: | 1719 (查看编码区序列) |
| 翻译后氨基酸长度: | 572 (查看氨基酸序列) |
| Transcript Variant: | This variant (1) represents the longer transcript and encodes the longer isoform (a). |
| 人 GPNMB (NM_001005340) cDNA克隆 | transcript variant 1 |
| 人 GPNMB (NM_002510) cDNA克隆 | transcript variant 2 |
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