人 UBQLN1 (NM_053067) cDNA克隆

Accession: NM_053067
基因名称: UBQLN1
基因别名: DA41; DSK2; UBQN; XDRP1; PLIC-1
基因描述: Homo sapiens ubiquilin 1 (UBQLN1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1686 (查看编码区序列)
翻译后氨基酸长度: 561 (查看氨基酸序列)
Transcript Variant: This variant (2) is missing an alternate 3' coding exon, compared to transcript variant 1. The resulting protein (isoform 2) is 28 aa shorter when compared to isoform 1.
产品编号 产品名称 载体 规格 价格
G112382 人 UBQLN1 (NM_053067) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]